Yes, any Debian / Ubuntu based distribution will work with the equalizer. However if you are not willing to do some command line, I recommend to stick with Win10 or look at OSMC.
So how I see it:
WIN 10 - apo - you have the experience, think this is the fasted way forward for you.
OSMC - you will need raspberry pi or vero box. Currently the equalizer and compressor will run on it (I havn't tested the vero box, though).
Linux - Ubuntu / Mint Desktop - will work mostly without command line, however sometimes it is faster / easier to do some command line.
In both cases you would need to set up Kodi in autostart.
I personally think a Mediabox should directly boot into Kodi. For this I wrote a sample setup for debian headless install, I haven't tested it the last 10 months, though.
This is pure command line, however you might get away with just copy - paste.
Example Setup on Debain Headless.
I personally would not purchase a raspberry pi unless you want to save some few watts in power consumption (I guess amortization in 10 years), or save some physical space, or upgrade to 4k. I think the N3450 outperforms the pi by far, which results in nicer menu reaction time.
If you want a new hardware, you could have a look at
OSMC. I wrote a
addon, which does the setup of the equalizer / compressor automatically, however I am not sure whether I will continue to support this long term as the interest on this is quite low. Currently you could set-up everything without command line or deal with technical stuff.
I also want to point you to the
Digital Room Correction thread, in some cases you could define a profile as acoustic therapy for tinitus treatment by suppressing the specific frequencies. This improved my tinitus a bit.